Biology and Diagnosis Committee (B&D)

Committee Chairman:

Christine Harrison

Committee Members:

S. Izraeli, M. Stanulla, G. Cario, A. Borkhardt, C. Eckert, L.H. Meyer, K.M. Debatin, R. Marschalek, B. Schlegelberger, A. Moorman, C. Harrison, J. Irving, R. Sutton, G. Cazzaniga, T. te Kronnie, G. Basso, H. Cave, T. Szczepanski, O. Haas, R. Panzer-Grümayer, A. Attarbaschi, M. Dworzak, M. den Boer, J.J. van Dongen, J. Zuna, E. Mejstrikova, O. Hrusak, M. Zaliova and many other regular and irregular participants

Clinical Trials:

Open:

N/A

Completed:

  • iBFM/PdL study on ABL1-class translocations in B-other ALL (coordinated by Harrison)
  • iBFM study on PAX5 amplification in BCP-ALL (coordinated by Harrison)
  • MPAL diagnosis and treatment outcome (data collection study by Hrusak in collaboration with the genomics study by H. Inaba/C. Mullighan)
  • Genomics and drug profiling of TCF3-HLF positive ALL (P. Bourquin)
  • A novel integrated cytogenetic and genomic classification of High-risk childhood ALL: an international validation (coordinated by Moorman)
  • I-BFM ALL Host Genetic Variation Working Group (coordinated by Christian Peter Kratz, Martin Stanulla, Hélène Cavé)

Activities/Projects:

N/A

Recent Publications:

Special issue of Eur J Med Genet (March 2016) introduced by the summary article:

Genetic predisposition to acute lymphoblastic leukemia: Overview on behalf of the I-BFM ALL Host Genetic Variation Working Group. Kratz CP, Stanulla M, Cavé H. Eur J Med Genet. 2016 Mar;59(3):111-5. doi: 10.1016/j.ejmg.2015.10.003. Epub 2015 Dec 15.

Selected collaborative publications of the BD members:

New cellular markers at diagnosis are associated with isolated central nervous system relapse in paediatric B-cell precursor acute lymphoblastic leukaemia. van der Velden VH, de Launaij D, de Vries JF, de Haas V, Sonneveld E, Voerman JS, de Bie M, Revesz T, Avigad S, Yeoh AE, Swagemakers SM, Eckert C, Pieters R, van Dongen JJ. Br J Haematol. 2016 Mar;172(5):769-81. doi: 10.1111/bjh.13887. Epub 2015 Dec 21.

Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Fischer U, Forster M, Rinaldi A, Risch T, Sungalee S, Warnatz HJ, Bornhauser B, Gombert M, Kratsch C, Stütz AM, Sultan M, Tchinda J, Worth CL, Amstislavskiy V, Badarinarayan N, Baruchel A, Bartram T, Basso G, Canpolat C, Cario G, Cavé H, Dakaj D, Delorenzi M, Dobay MP, Eckert C, Ellinghaus E, Eugster S, Frismantas V, Ginzel S, Haas OA, Heidenreich O, Hemmrich-Stanisak G, Hezaveh K, Höll JI, Hornhardt S, Husemann P, Kachroo P, Kratz CP, Kronnie GT, Marovca B, Niggli F, McHardy AC, Moorman AV, Panzer-Grümayer R, Petersen BS, Raeder B, Ralser M, Rosenstiel P, Schäfer D, Schrappe M, Schreiber S, Schütte M, Stade B, Thiele R, Weid Nv, Vora A, Zaliova M, Zhang L, Zichner T, Zimmermann M, Lehrach H, Borkhardt A, Bourquin JP, Franke A, Korbel JO, Stanulla M, Yaspo ML. Nat Genet. 2015 Sep;47(9):1020-9. doi: 10.1038/ng.3362. Epub 2015 Jul 27.

Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study. Boer JM, van der Veer A, Rizopoulos D, Fiocco M, Sonneveld E, de Groot-Kruseman HA, Kuiper RP, Hoogerbrugge P, Horstmann M, Zaliova M, Palmi C, Trka J, Fronkova E, Emerenciano M, do Socorro Pombo-de-Oliveira M, Mlynarski W, Szczepanski T, Nebral K, Attarbaschi A, Venn N, Sutton R, Schwab CJ, Enshaei A, Vora A, Stanulla M, Schrappe M, Cazzaniga G, Conter V, Zimmermann M, Moorman AV, Pieters R, den Boer ML. Leukemia. 2016 Jan;30(1):32-8. doi: 10.1038/leu.2015.199. Epub 2015 Jul 23.

Minimal residual disease analysis by eight-color flow cytometry in relapsed childhood acute lymphoblastic leukemia. Karawajew L, Dworzak M, Ratei R, Rhein P, Gaipa G, Buldini B, Basso G, Hrusak O, Ludwig WD, Henze G, Seeger K, von Stackelberg A, Mejstrikova E, Eckert C. Haematologica. 2015 Jul;100(7):935-44. doi: 10.3324/haematol.2014.116707. Epub 2015 May 22.

ERG deletion is associated with CD2 and attenuates the negative impact of IKZF1 deletion in childhood acute lymphoblastic leukemia. Zaliova M, Zimmermannova O, Dörge P, Eckert C, Möricke A, Zimmermann M, Stuchly J, Teigler-Schlegel A, Meissner B, Koehler R, Bartram CR, Karawajew L, Rhein P, Zuna J, Schrappe M, Cario G, Stanulla M. Leukemia. 2015 May;29(5):1222. doi: 10.1038/leu.2015.77. No abstract available.

KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia. Malinowska-Ozdowy K, Frech C, Schönegger A, Eckert C, Cazzaniga G, Stanulla M, zur Stadt U, Mecklenbräuker A, Schuster M, Kneidinger D, von Stackelberg A, Locatelli F, Schrappe M, Horstmann MA, Attarbaschi A, Bock C, Mann G, Haas OA, Panzer-Grümayer R. Leukemia. 2015 Aug;29(8):1656-67. doi: 10.1038/leu.2015.107. Epub 2015 Apr 28.

Central nervous system acute lymphoblastic leukemia: role of natural killer cells. Frishman-Levy L, Shemesh A, Bar-Sinai A, Ma C, Ni Z, Frenkel S, Muench V, Bruckmueller H, Vokuhl C, Debatin KM, Eckert C, Stanulla M, Schrappe M, Campbell KS, Loewenthal R, Schewe DM, Hochman J, Meyer LH, Kaufman D, Cario G, Porgador A, Izraeli S. Blood. 2015 May 28;125(22):3420-31. doi: 10.1182/blood-2014-08-595108. Epub 2015 Apr 20. Erratum in: Blood. 2015 Jul 16;126(3):425.

Fine tuning of surface CRLF2 expression and its associated signaling profile in childhood B-cell precursor acute lymphoblastic leukemia. Bugarin C, Sarno J, Palmi C, Savino AM, te Kronnie G, Dworzak M, Shumich A, Buldini B, Maglia O, Sala S, Bronzini I, Bourquin JP, Mejstrikova E, Hrusak O, Luria D, Basso G, Izraeli S, Biondi A, Cazzaniga G, Gaipa G; I-BFM study group. Haematologica. 2015 Jun;100(6):e229-32. doi: 10.3324/haematol.2014.114447. Epub 2015 Apr 10. No abstract available.

Refinement of IKZF1 status in pediatric Philadelphia-positive acute lymphoblastic leukemia. Lana T, de Lorenzo P, Bresolin S, Bronzini I, den Boer ML, Cavé H, Froňková E, Stanulla M, Zaliova M, Harrison CJ, de Groot H, Valsecchi MG, Biondi A, Basso G, Cazzaniga G, te Kronnie G. Leukemia. 2015 Oct;29(10):2107-10. doi: 10.1038/leu.2015.78. Epub 2015 Mar 17. No abstract available.

Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment. Eckert C, Hagedorn N, Sramkova L, Mann G, Panzer-Grümayer R, Peters C, Bourquin JP, Klingebiel T, Borkhardt A, Cario G, Alten J, Escherich G, Astrahantseff K, Seeger K, Henze G, von Stackelberg A. Leukemia. 2015 Aug;29(8):1648-55. doi: 10.1038/leu.2015.59. Epub 2015 Mar 9.

Childhood acute lymphoblastic leukemia-associated risk-loci IKZF1, ARID5B and CEBPE and risk of pediatric non-Hodgkin lymphoma: a report from the Berlin-Frankfurt-Münster Study Group. Bartram T, Burkhardt B, Wössmann W, Seidemann K, Zimmermann M, Cario G, Lisfeld J, Ellinghaus E, Franke A, Houlston RS, Schrappe M, Reiter A, Stanulla M. Leuk Lymphoma. 2015 Mar;56(3):814-6. doi: 10.3109/10428194.2014.933479. Epub 2014 Aug 13. No abstract available.

Meetings:

Recent:

  • I-BFM-SG Interim Meeting of ALL+B&D Committees Palazzo delle Stelline, Milan (Italy) – January 22-23, 2018
  • I-BFM-SG Annual Meeting, Jerusalem (Israel) – May 10-12, 2017

Next:

N/A

Contact:

Christine Harrison    christine.harrison@newcastle.ac.uk